Perindopril erbumine ( —— )

产品货号. M10292 CAS No. 107133-36-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Perindopril erbumine
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

PERINDOPRIL ERBUMINE 是一种血管紧张素转换酶抑制剂。
产品描述

PERINDOPRIL ERBUMINE is an angiotensin-converting enzyme inhibitor. It is used in patients with hypertension and heart failure.
体外实验

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体内实验

Animal Model:Adenine-induced chronic kidney disease ratsDosage:0.1 mg/kg Administration:Oral gavage (p.o.)Result:Abolished the LPS-induced astroglial and microglial activation.Attenuated LPS-induced TNF-α production.Prevented LPS-induced nuclear translocation of NF-кB.Prevented the AT1R up-regulation and the LPS-induced decrease in the expression of PP2A.Animal Model:Chronic kidney disease rats Dosage:0.42 mg/kg Administration:Oral Result:Obviously reduced serum creatinine (Scr) and blood urea nitrogen (BUN) levels.Displayed a marked reduction of tubulointerstitial fibrosis.Exhibited more inhibitory effect on Col-IV expression and a exceed effect of raising OPA-1 expression.Significantly increased Sirtuin3 expression.
同义词

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通路

Endocrinology/Hormones
靶点

MRP
受体

MRP1| ACE
研究领域

Cardiovascular Disease
适应症

——

CAS Number

107133-36-8
分子量

441.61
分子式

C23H43N3O5
纯度

>98% (HPLC)
溶解度

Ethanol: 88 mg/mL (199.27 mM); Water: 88 mg/mL (199.27 mM)
SMILES

CCC[C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@H]2CCCC[C@H]2C[C@H]1C(=O)O.CC(C)(C)N
化学全称

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1.Ceconi C, et al. Eur J Pharmacol, 2007, 577(1-3), 1-6.

计算器

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